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	Provedor de dados BJMBR (2) Autor Costa,E.H. (2) Simioni,P.U. (2) Tamashiro,W.M.S.C. (2) Cecílio,C.A. (1) Gabriel,D.L. (1) Palavra-chave Aging (2) Cytokines (2) Antibody (1) Arginase (1) INOS (1) Inflammatory stimuli (1) Murine macrophages (1) Proliferation (1) T cell response (1) T cell subsets (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Aging alters the production of iNOS, arginase and cytokines in murine macrophages BJMBR Cecílio,C.A.; Costa,E.H.; Simioni,P.U.; Gabriel,D.L.; Tamashiro,W.M.S.C.. The limited amount of information on the primary age-related deficiencies in the innate immune system led us to study the production of inducible nitric oxide synthase (iNOS), arginase, and cytokines in macrophages of young (8 weeks old) and old (72 weeks old) female BALB/c mice. We first evaluated iNOS and arginase inducers on peritoneal (PMΦ) and bone marrow-derived (BMMΦ) macrophages of young BALB/c and C57BL/6 mice, and then investigated their effects on macrophages of old mice. Upon stimulation with lipopolysaccharide (LPS), resident and thioglycolate-elicited PMΦ from young mice presented higher iNOS activity than those from old mice (54.4%). However, LPS-stimulated BMMΦ from old mice showed the highest NO levels (50.1%). Identical NO levels were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; INOS; Arginase; Cytokines; Murine macrophages; Inflammatory stimuli. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700010 Aging reduces the primary humoral response and the in vitro cytokine production in mice BJMBR Simioni,P.U.; Costa,E.H.; Tamashiro,W.M.S.C.. Aging is accompanied by a decrease in several physiological functions that make older individuals less responsive to environmental challenges. In the present study, we analyzed the immune response of female BALB/c mice (N = 6) of different ages (from 2 to 96 weeks) and identified significant age-related alterations. Immunization with hapten-protein (trinitrophenyl-bovine serum albumin) conjugates resulted in lower antibody levels in the primary and secondary responses of old mice (72 weeks old). Moreover, young mice (2, 16, and 32 weeks old) maintained specific antibodies in their sera for longer periods after primary immunization than did old mice. However, a secondary challenge efficiently induced memory in old mice, as shown by the increased antibody... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; Cytokines; Antibody; Proliferation; T cell response; T cell subsets. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800012 Registros recuperados: 2 Primeira ... 1 ... Última

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